This report describes the burden of acute disease attributed to infection with the hepatitis A, hepatitis B, and hepatitis C viruses, and describes acute disease trends in recent years. Cases of acute viral hepatitis are reported weekly by state and territorial health departments to CDC's National Notifiable Diseases Surveillance System. The report includes the methods of collecting data, definitions for acute viral hepatitis, and analyses. The report provides incidence and rates by region, age, sex, race and ethnicity, risk factors, and clinical characteristics for hepatitis A, B, and C by type and year in the United States from 1966 to 2006.