The prevalence of obesity is increasing in people with HIV (PWH), contributing to multiple complications associated with this condition. There is mounting evidence that there are unique mechanisms contributing to the development of obesity in PWH versus people without HIV. Furthermore, the biology of the adipocytes might be altered in overweight or obese PWH versus overweight or obese people without HIV.
This Funding Opportunity Announcement (FOA) encourages Research Conference Grant (R13) applications to conduct an annual intensive workshop/conference/meeting that addresses the needs of early stage HIV/AIDS researchers utilizing nonhuman primates (NHPs) as they translate preclinical research from NHPs to human clinical trials.
The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Clinical Trials Units (CTUs) to provide scientific and administrative expertise as well as the infrastructure to conduct clinical studies developed by NIH HIV/AIDS Clinical Trials Networks. Clinical Trials Units will participate in the development of trials and provide clinical sites, local laboratory capacity, and pharmacy support for two or more HIV/AIDS Clinical Trials Networks.
The objective of this Funding Opportunity Announcement (FOA) is to support the evaluation of early stage diagnostics and novel diagnostic strategies for Tuberculosis (TB) in the context of existing clinical diagnostic algorithms in TB endemic countries. Evaluation studies should focus on: 1) proof-of principle studies of novel diagnostic tests and strategies and 2) provide feedback to diagnostic developers on the performance of the technology and most effective strategy for use of a diagnostic technology in an endemic setting.
The purpose of this Funding Opportunity Announcement (FOA) is to support basic science research, from early exploratory studies to therapeutic discovery and development, in novel biologically active viral and/or host RNAs involved in virology (including HIV biology) and immune regulation.
To support generation of single cell datasets for one or more brain regions relevant to opioid use disorder and persistent HIV infection. If fully successful, this project will generate 1. A cellular parts list for selected NIDA-relevant brain regions, 2. Reveal how cell types within these brain regions differ from one another with respect to gene expression, 3. Reveal how cell types within these brain regions are altered by chronic opioid exposure providing potential novel therapeutic targets for opioid addiction, 4.
Along with RFA-DA-19-037, which will support the generation of single cell datasets for one or more brain regions relevant to opioid use disorder and persistent HIV infection, a data coordination/analysis/outreach center (RFA-DA-19-038) will be established to make NIDA-funded single cell data and other molecular HIV/SUD data FAIR (Findable, Accessible, Interoperable, and Reusable). Harmonized single cell HIV/SUD data sets will enable immediate data mining by the scientific community for HIV and/or SUD biomarkers and potential pathways for therapeutic intervention.
The objective of this FOA is to advance non-sputum-based tuberculosis (TB) diagnostics for use in HIV-1 infected and HIV-1 exposed uninfected children (HEU) for improved, simplified, rapid and decentralized diagnosis of TB disease. This opportunity will support discovery and validation of novel biomarkers useful for TB diagnosis or the development/optimization and early validation of novel TB diagnostic technologies.
This Funding Opportunity Announcement (FOA) encourages formative research, intervention development, and pilot-testing of interventions. Primary scientific areas of focus include the feasibility, tolerability, acceptability and safety of novel or adapted interventions that target HIV prevention, treatment or services research.