This report updates previous US Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and other body fluids that may contain Hepatitis B, Hepatitis C, or HIV/AIDS. It contains recommendations for Hepatitis B Virus postexposure management including initiation of hepatitis B vaccine series to any susceptible, unvaccinated person who sustains blood or body fluid exposure. Guidance is provided to clinicians and exposed HCP for selecting the appropriate HBV postexposure prophylaxis (PEP). In addition, the report outlines several special circumstances including delayed exposure report, unknown source person, pregnancy in the exposed person, resistance of the source virus to antiretroviral agents, or toxicity of the PEP regimen when other consultation is advised.