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Streamlining mental health interventions for youth living with HIV in Low- and Middle-Income Countries (R01 Clinical Trial Optional)

This initiative would solicit research to target gaps in our knowledge about how best to address the mental health needs of YLWH in low- and middle-income countries in ways that are easy to scale up. There are two main goals of the initiative. The first is to increase the number of mental health interventions that are tailored to the unique needs of adolescents living with HIV, both in terms of their developmental needs as well as the issues they have to attend to as a result of living with a chronic, stigmatized disease.

Addressing the Impact of Syndemics on the Health of People with HIV and Diseases and Conditions within the Missions of NIDDK and NHLBI (R01 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) invites research projects that seek solutions to the development, exacerbation, and ineffective management of co-occurring conditions in marginalized communities of People with HIV (PWH). Projects must be based on a syndemics (synergistic epidemic) framework with a focus on the impact of racism, marginalization, discrimination, and/or stigma and their inter-relationships with social and structural risks.

Advancing Technologies to Improve Delivery of Pharmacological, Gene Editing, and other Cargoes for HIV and SUD Mechanistic or Therapeutic Research (R01 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to develop technologies to improve the delivery of pharmacological, gene editing, or other cargoes for HIV and substance use disorder (SUD) mechanistic or therapeutic research.

Effect of HIV and Substance Use Comorbidity on the Placenta and Maternal Outcomes (R01 Clinical Trial Optional)

Human immunodeficiency virus (HIV) infection is widely prevalent in individuals in the reproductive age group. Globally, an estimated 1.3 million people living with HIV (PWH) become pregnant each year (UNAIDS data, 2019). With the advent of antiretroviral therapy (ART), significant progress has been made in the prevention of vertical transmission of HIV. However, although ART has clear benefits in preventing vertical transmission, ART regimens are associated with higher rates of preterm birth, stillbirth, and early infant death.

HIV Vaccine Research and Design (HIVRAD) Program (P01 Clinical Trial Not Allowed)

The purpose of this Notice of Funding Opportunity (NOFO) is to support multi-component, multi-disciplinary projects that address scientific questions relevant to AIDS prophylactic vaccine discovery research. Extensive evaluation of vaccine concepts in non-human primate models may be included.

Interventions to Address HIV-Related Comorbidities among Highly Affected Populations Experiencing Health Disparities (R01 - Clinical Trial Required)

This initiative will support multilevel and multidisciplinary intervention research to improve quality of life and promote successful aging among people with HIV with HIV associated non-AIDS comorbidities across the life course from racial and ethnic and lower socioeconomic status groups.