This report provides World Health Organization (WHO) member states with guidance on preventing TB transmission in healthcare facilities, congregate settings, and households. It focuses on what to do and how to prioritize TB infection control at national levels and includes recommendations for national managerial activities. The report updates or presents new or increased emphasis on the particular administrative and environmental controls to be implemented and on personal protective equipment. It includes a special focus on building design and use of space. The policy also describes how to prioritize TB infection control measures, depending on the burden of TB, HIV, and multidrug-resistant TB. The policy explains that political, institutional, and financial commitment are necessary for the success of this program.