This article provides a comprehensive overview of Doxycycline Post-Exposure Prophylaxis (Doxy-PEP), an antibiotic used to reduce the risk of bacterial sexually transmitted infections (STIs) such as chlamydia, gonorrhea, and syphilis following condomless sex. It explains how Doxy-PEP works, the correct dosage and timing (200 mg within 24–72 hours after exposure), and who should or should not take it, including guidance for pregnant individuals. The article discusses potential side effects, interactions with other medications, and considerations regarding antibiotic resistance. It emphasizes that Doxy-PEP does not prevent viral infections, including HIV, highlighting the importance of additional preventive measures like condoms, regular STI testing, HIV PrEP/PEP, and vaccinations. Guidance is provided for safely incorporating Doxy-PEP into a sexual health routine, including repeated dosing, precautions, and when to seek medical attention for STI symptoms. Overall, the article serves as an educational resource for individuals seeking to reduce their risk of bacterial STIs and maintain sexual health.
- Adults
- At Risk Persons
- Health Educators/Communicators
- Men
- Men Who Have Sex with Men (MSM)
- Viral Hepatitis
- Doxy PEP

