This article examines the ongoing challenge of rising HIV infections in the United States and its implications for ending the epidemic. Despite over 40 years of scientific and medical advancements—including widespread access to antiretroviral therapy (ART), single-pill regimens, long-acting injectables, and pre-exposure prophylaxis (PrEP)—new HIV infections remain disproportionately high among Black and Latine communities. The article highlights the transformative impact of biomedical interventions, such as ART enabling viral suppression (“Undetectable = Untransmittable”) and biannual injectable PrEP, while emphasizing persistent disparities in access and awareness. Key barriers to ending the epidemic include stigma, lack of knowledge, and potential federal funding cuts that threaten HIV prevention and treatment programs. The article underscores the crucial role of healthcare providers, particularly Black providers, in normalizing discussions around PrEP, testing, and sexual health. It also calls for collective action across individuals, healthcare systems, corporations, and faith-based organizations to promote equitable access to prevention and treatment. By combining culturally competent care, community outreach, and policy advocacy, the article advocates for a sustained, multi-level approach to reducing infections and ultimately ending the HIV epidemic.
- Adults
- Advocates
- At Risk Persons
- Black or African American persons
- Health Professionals
- Hispanic or Latino persons
- HIV and AIDS
- Adults
- Black or African American persons
- HIV

