MMWR: Clinical Update: Impact of HIV Protease Inhibitors on the Treatment of HIV - Infected Tuberculosis Patients With Rifampin

This report describes approaches for managing patients with TB who are candidates for or who are undergoing protease inhibitor therapy and presents interim recommendations for managing these patients until additional data are available and formal guidelines are issued. Protease inhibitors interact with rifamycin derivatives, which are used to treat and prevent the mycobacterial infections commonly observed in patients with the HIV. The report provides background information on the management of TB and the three treatment options currently available for these patients. The concurrent use of protease inhibitors with rifampin might be possible by modifying the doses of both to compensate for the drug interaction.