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CDC STD Guidelines and Recommendations

Sexually Transmitted Diseases Treatment Guidelines, 2015

The 2015 guidelines update the edition released in 2010. Although these guidelines emphasize treatment, prevention strategies and diagnostic recommendations also are discussed.


These guidelines provide a resource to assist physicians, and other health-care workers, who play a critical role in preventing and treating STDs. The recommendations were created for any patient-care setting that serves people who have an STD or are at-risk of becoming infected with an STD. They should be used as a source of guidance to treat patients and not prescriptive standards; each patient’s clinical circumstances should be considered independently. These guidelines were developed by CDC staff and an independent workgroup, who were charged with identifying key questions regarding treatment and clinical management that were not addressed in the 2010 STD Treatment Guidelines.

These guidelines include:

  1. Alternative treatment regimens for Neisseria gonorrhoeae;
  2. The use of nucleic acid amplification tests for the diagnosis of trichomoniasis;
  3. Alternative treatment options for genital warts;
  4. The role of Mycoplasma genitalium in urethritis/cervicitis and treatment-related implications;
  5. Updated HPV vaccine recommendations and counseling messages;
  6. The management of persons who are transgender;
  7. Annual testing for hepatitis C in persons with HIV infection;
  8. Updated recommendations for diagnostic evaluation of urethritis; and
  9. Retesting to detect repeat infection.

Physicians and other health-care providers can use these guidelines to assist in the prevention and treatment of STDs.

Program Tools

NNPTC Online Case Series

From CDC and the National Network of STD/HIV Prevention Training Centers (NNPTC), a web-based case series that is designed for practicing clinicians who diagnose, treat, and manage patients with, or at risk for, sexually transmitted diseases (STDs).

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