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Persons with HIV/AIDS

Supporting Counties and Other Indigenous Health Management Institutions to Bridge Skill Gaps Among Health Care Workforce Necessary for HIV Epidemic Control in Kenya under the President's Emergency Plan for AIDS Relief (PEPFAR)

The necessary skills required for HIV epidemic control in Kenya are not adequately offered during pre-service trainings of health care workers due to delayed alignment of training curricula with emerging health issues. There is also low deployment of graduating health care workers, thus leaving a large skill gap, especially in areas that have traditionally not been the focus of pre-service training such as monitoring and evaluation, health informatics, and epidemiology.

Scaling High Quality Laboratory Services for HIV Diagnosis, Care, Treatment and Monitoring in Mozambique under the President's Emergency Plan for AIDS Relief (PEPFAR)

Laboratory services, and their networks, are fundamental components of effective, well-functioning health systems and are essential for patient management, disease detection and control, and surveillance. This NOFO will support Mozambique’s Ministry of Health (MOH) to strengthen the integrated national laboratory network in order to ensure the provision of quality services for clinical diagnosis, screening, and surveillance in support of HIV care and treatment and the achievement of an AIDS free generation.

Strengthen Capacity of South African Government's Department of Health and Implementing Partners to Deliver Quality Differentiated, Advanced Clinical Care for Unstable HIV and TB/HIV Patients in the Republic of South Africa under PEPFAR

In South Africa, it is estimated that 20% of patients newly initiating anti-retroviral therapy (ART) present late and 10-15% of patients on first line ART are failing treatment, leading to poor retention, especially in the first 12 months of treatment. This NOFO seeks to improve treatment retention and viral load suppression of HIV and TB/HIV co-infected patients through the use of innovative capacity building approaches for health service providers to better manage complicated and unstable HIV and TB/HIV co-infected patients.

Characterization of Mycobacterial Induced Immunity in HIV-infected and Uninfected Individuals (R21 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to support innovative studies to identify and understand the immunological responses that mediate protection from Mycobacterium tuberculosis (Mtb) infection or following vaccination with Bacillus Calmette-Gurin (BCG) or investigational vaccines. Studies may focus on any stage of mycobacterial infection and may include HIV-infected or uninfected individuals. Development of novel functional assays to assess host response and inclusion of immune profiling and systems biology approaches are encouraged.

HIV Prevention, Care, and Treatment Support for Church-related Hospitals and Clinics in the Republic of Zimbabwe under the President's Emergency Plan for AIDS Relief (PEPFAR)

Zimbabwe has a generalized HIV epidemic with an estimated 1.4 million people living with HIV (PLHIV). Adult prevalence aged 15-49 is 14.0%, down from 18.1% in 2015. Incidence among adults is 0.47%, and the 18-month mother to child transmission (MTCT) rate is 6.74%. However, testing, treatment, and viral suppression coverage all lag behind the 95-95-95 targets. Zimbabwe’s Ministry of Health and Child Care (MOHCC) has highlighted human resource challenges across the continuum of service delivery.

Modeling HIV Neuropathology Using Microglia from Human iPSC and Cerebral Organoids (R01 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) invites research grant applications to study the cellular and molecular mechanisms delineating the neuropathophysiology of HIV-associated neurological disorders (HAND) in the setting of long-term combination antiretroviral therapy (cART) conditions using induced microglia and cerebral organoids generated from patient derived induced pluripotent stem cell (iPSC) lines.

Optimizing Performance by Improving Quality (OPIQ) in HIV and HIV/TB Programs in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)

The goal of this NOFO is to improve performance of HIV and TB key indicators and programmatic areas by providing technical assistance (TA) using Quality Improvement (QI) methodologies to PEPFAR South Africa’s implementing partners (IPs) and the South African Government’s (SAG) National, Provincial, and District Departments of Health (DOH).

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