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Persons with HIV/TB

Strengthen Capacity of South African Government's Department of Health and Implementing Partners to Deliver Quality Differentiated, Advanced Clinical Care for Unstable HIV and TB/HIV Patients in the Republic of South Africa under PEPFAR

In South Africa, it is estimated that 20% of patients newly initiating anti-retroviral therapy (ART) present late and 10-15% of patients on first line ART are failing treatment, leading to poor retention, especially in the first 12 months of treatment. This NOFO seeks to improve treatment retention and viral load suppression of HIV and TB/HIV co-infected patients through the use of innovative capacity building approaches for health service providers to better manage complicated and unstable HIV and TB/HIV co-infected patients.

Optimizing Performance by Improving Quality (OPIQ) in HIV and HIV/TB Programs in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)

The goal of this NOFO is to improve performance of HIV and TB key indicators and programmatic areas by providing technical assistance (TA) using Quality Improvement (QI) methodologies to PEPFAR South Africa’s implementing partners (IPs) and the South African Government’s (SAG) National, Provincial, and District Departments of Health (DOH).

Building and Improving Laboratory Capacity and Quality in the Democratic Republic of Congo (DRC) under the President's Emergency Plan for AIDS Relief (PEPFAR)

Access to quality assured diagnostics and laboratory services is critical to the effective diagnosis, treatment, and management of HIV and other HIV-related diseases, including TB. Achieving the UNAIDS 95-95-95 targets requires establishment and operationalization of laboratory and diagnostic networks.PEPFAR DRC supported laboratory and integrated diagnostic network strengthening efforts have led to improved access to the quality diagnostic and patient monitoring services. The data reports show improved viral load (VL) coverage from 27% to 56% in FY16 and FY17 and 75% suppression rate.

A Guide to Monitoring and Evaluation for Collaborative TB/HIV Activities

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This monograph is a guide to monitoring and evaluating the collaborative TB/HIV activities. It presents a rationale for collaborative activities, an overview of monitoring indicators, methods of collecting standardized data, and help in interpreting and disseminating the data. It argues for consistency in the way collaborative activities are performed and data collected. The guide presents a core set of internationally accepted and standardized indicators for measuring and evaluating performance.

Tuberculosis and AIDS

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This report, for health professionals, government agencies, and organizations, presents information about HIV/AIDS and TB. It provides epidemiological statistics concerning the relationship between HIV/AIDS and TB, including incidence, morbidity rates, and mortality rates. It discusses TB and HIV transmission, how HIV can facilitate the development of active TB, and recommendations for the prevention of TB among HIV-positive persons.

MMWR: Updated Guidelines for the Use of Rifabutin or Rifampin for the Treatment and Prevention of Tuberculosis Among HIV-Infected Patients Taking Protease Inhibitors or Nonnucleoside Reverse Transcriptase Inhibitors

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This report presents updated data pertaining to drug-drug-interactions between protease inhibitors and nonnucleoside reverse transcriptase inhibitors (NNRTIs) for treatment of HIV and rifamycins for the treatment of TB. The notice also presents recommendations for the use of these drugs. New data indicate that rifampin can be used for the treatment of active TB in three situations.

MMWR: Drug-Susceptible Tuberculosis Outbreak in a State Correctional Facility Housing HIV-Infected Inmates--South Carolina, 1999-2000

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This report describes an investigation of an outbreak of drug-susceptible TB in a South Carolina correctional facility housing inmates infected with HIV. The source inmate was not receiving antiretroviral treatment and two attempts to treat his latent TB infection were discontinued because of side effects. However, he was not placed in respiratory isolation. When a former dormitory inmate who had been released tested positive for pulmonary TB, a contact investigation of inmates from that dormitory was begun. Of 323 men, 31 were diagnosed with TB.

TB/HIV: Strategic Framework to Decrease the Burden of TB/HIV

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This monograph provides the technical basis to inform and guide the development of national implementation strategies for joint TB and HIV program activities in delivering the available interventions. The monograph describes the background to the global problem of HIV-related TB, and includes a brief review of global HIV epidemiology, the causes of the main burden of HIV-related disease, the epidemiology of HIV-related TB, and the place of TB in the course of progression of HIV infection.

HIV Voluntary Counselling and Testing: A Gateway to Prevention

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This monograph presents five case studies of programs in South Africa, Zambia, and Zimbabwe that used voluntary counseling and testing (VCT) to control the spread of HIV. The monograph describes how the programs used VCT to help prevent perinatal HIV transmission, TB, and HIV transmission among adolescents and general populations. It also discusses general VCT approaches and issues related to program development, administration, and evaluation.

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