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Antiretroviral Drugs

Strengthening Capacity of HIV/AIDS Treatment in Ukraine under the President's Emergency Plan for AIDS Relief (PEPFAR)

Grantee will work at Ukrainian priority regional AIDS Centers and antiretroviral (ARV) treatment sites to provide technical assistance on implementation of test and treat guidelines and on innovative service delivery models for resource optimization. Grantee will also work at national level to provide input into development of national guidelines and policy on HIV testing, care and treatment.

Strengthening Clinical Services for People Living with HIV (PLHIV) in Central America under the President's Emergency Plan for AIDS Relief (PEPFAR)

This funding opportunity announcement (FOA) seeks to improve clinical services among People Living with HIV (PLHIV) in the Central America Region including Guatemala, El Salvador, Honduras, Nicaragua, and Panama.This project will require joint collaboration between the Ministry of Health (MOH), other governmental entities, Non-Governmental Organizations (NGOs) and the Centers for Disease Control (CDC) in order to effectively reach the target population and support sustainable clinical services.

Supporting Local Indigenous Faith-Based Partners in Providing High Quality HIV Care, Prevention and Treatment Services and Improving Linkage and Retention in the Republic of Guyana under the President's Emergency Plan for AIDS Relief (PEPFAR)

The purpose of this FOA in Guyana is to provide technical assistance and funding to local indigenous organizations to improve access to quality Antiretroviral therapy (ART) clinical services. Activities will focus on delivering tailored services for key populations, improving linkage to care, retention on ART and will ensure sustainable service delivery within faith based-affiliated sites in Guyana.

Delivering Comprehensive Services to Achieve HIV Epidemic Control in Subnational Units in Nigeria under the President's Emergency Plan for AIDS Relief (PEPFAR)

This follow-on FOA will sustain and enhance the delivery of comprehensive HIV/AIDS service packages in the Federal Republic of Nigeria. This will be accomplished by employing proven strategies and service delivery models to achieve and sustain epidemic control in Nigeria. This program will support facility and community based provision of HIV/AIDS prevention, treatment and support services in targeted geographic locations and populations.

Mechanisms of Immune Activation and Inflammation: HIV Infection, ART, and Drugs of Abuse (R01)

The purpose of this FOA is to promote research to investigate the underlying molecular mechanisms of HIV infection-induced immune activation and inflammation in the presence of antiretroviral therapy (ART) agents and drugs of abuse. The ultimate goal is to obtain information for developing therapeutic interventions for attenuating chronic inflammation-associated comorbidities as well as for restoring or improving ART efficacy in HIV-infected drug-abusing populations.

Understanding HIV Rebound (P01)

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The purpose of this Funding Opportunity Announcement (FOA) is to support multi-disciplinary, Program Project applications aimed at understanding specific mechanisms, biomarkers, and pathways associated with rebound of HIV viremia.

Advancing HIV Therapeutic Vaccine Science (U01)

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This Funding Opportunity Announcement (FOA) solicits applications that will advance understanding of vaccine regimens and immune responses that sustainably suppress viral loads in HIV-infected individuals. Applications should propose small, multi-arm, comparative clinical trials designed to identify correlations between levels of induced immune response and HIV virologic control. Vaccines may be combined with adjuvants and/or other modifiers of the immune response to HIV.

Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01)

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The goal of this Funding Opportunity Announcement (FOA) is to support innovative research in humans to elucidate the role of HIV infection, including relevant host conditions or antiretroviral therapy, on metabolic and endocrine dysfunction, as well as to support innovative research delineating the pathophysiology, etiology, risk or protective factors, and potential strategies to prevent, treat, or reverse endocrine and metabolic dysfunction in HIV-infected individuals. Proposed projects must involve human subjects with HIV infection or materials or data from HIV-infected individuals.

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