This report is a white paper outlining the vision of the Centers for Disease Control and Prevention’s (CDC’s) National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) for reducing health disparities and promoting health equity related to conditions of interest. NCHHSTP is committed to promoting awareness, engagement, and action on the many factors that can affect the health of all; to addressing these factors in the policy, practice, and research activities of NCHHSTP; and to building partnerships on every level. The paper outlines planned NCHHSTP activities and commitments for 2011-2015 to reduce health disparities related to HIV, viral hepatitis, STD, and TB infections, and promote health equity by addressing the social determinants of health (SDH). Six focus areas are identified for priority actions: research and surveillance, communication, policy, programs, capacity building, and partnerships.