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Home » Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: CNS Data Generation (UM1 Clinical Trial Not Allowed)

Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: CNS Data Generation (UM1 Clinical Trial Not Allowed)

To support generation of single cell datasets for one or more brain regions relevant to opioid use disorder and persistent HIV infection. If fully successful, this project will generate 1. A cellular parts list for selected NIDA-relevant brain regions, 2. Reveal how cell types within these brain regions differ from one another with respect to gene expression, 3. Reveal how cell types within these brain regions are altered by chronic opioid exposure providing potential novel therapeutic targets for opioid addiction, 4. Reveal how HIV infection in the CNS influences single cells, providing potential targets for improving HIV neurobiological sequelae, and 5. Uncover potential synergistic effects of chronic opioid exposure and HIV infection in the CNS. 

Letter of Intent Date
4/8/19
Application Due Date
5/8/19
Project Start Date
12/1/19
Application Contact
Aida
Vasquez
Grants Management Specialist
United States
301-480-2154
vasquez@mail.nih.gov
Technical Contact
John
Satterlee, Ph.D.
Health Scientist Administrator
satterleej@nida.nih.gov
United States
301-435-1020
Fund Duration
The maximum project period is 5 years.
Subjects
Audiences
Focus Area

Fund Number: 

5467

Fund ID: 

RFA-DA-19-037

Last Updated: 

4/5/19