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Home » Mechanisms of Mycobacterial-Induced Immunity in HIV-Infected and/or Uninfected Individuals to Inform Innovative Tuberculosis Vaccine Design (R01 Clinical Trial Not Allowed)

Mechanisms of Mycobacterial-Induced Immunity in HIV-Infected and/or Uninfected Individuals to Inform Innovative Tuberculosis Vaccine Design (R01 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to support innovative studies to identify and understand the immunological responses that mediate protection from Mycobacterium tuberculosis (Mtb) infection or progression to active tuberculosis (TB) disease. Such responses may be operative in mycobacterial infection, or following vaccination with Bacillus Calmette-Gurin (BCG) or investigational vaccines. Studies may focus on any stage of mycobacterial infection and may include HIV-infected and/or uninfected individuals. Research supported under this FOA should go beyond descriptive information currently known about Mtb infection, immune responses to TB vaccines, or immune modulation by non-tuberculous mycobacterial (NTM) infection, or by HIV/AIDS. Applications are sought that include characterization of the timing, anatomical location, and contribution to disease outcome, of mucosal and/or systemic immune responses to mycobacterial infection and/or vaccination. This research is expected to advance understanding of immune mechanisms in Mtb infection/vaccination and contribute to the advancement of new TB vaccines, including in populations also infected with HIV. 

Funding Category
Locations
National
Eligible Organizations
Number of Awards Given
Contingent upon NIH appropriations.
Award Amount Notes
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Application Due Date
1/14/20
Project Start Date
7/1/20
Application Contact
Ann
Devine
Branch Chief, Grants Management Officer/AIDS and CTU Division Coordinator
United States
240-669-2988
adevine@niaid.nih.gov
Technical Contact
Cesar
Boggiano, PhD
Scientific/Research Contact
cesar.boggiano@nih.gov
United States
240-627-3038
Fund Duration
The scope of the proposed project should determine the project period. The maximum project period is 5 years.
Subjects
Audiences
Focus Area

Fund Number: 

5488

Fund ID: 

PAR-19-307

Last Updated: 

7/2/19