The Deep South region (AL, FL, GA, LA, MS, NC, SC, TN, TX) has been particularly affected by HIV, having the highest diagnosis and death rates of any region in the US.1,2 This region has historically had high pov- erty rates, high levels of STIs and other diseases, and a cultural climate that generates significant HIV-relat- ed stigma, all of which contribute to the dispropor- tionate impact of HIV in the Deep South. COVID-19 has further exacerbated disparities for people across the US, and certain populations and regions have been disproportionately affect- ed.