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HIV/AIDS

Characterization of Mycobacterial Induced Immunity in HIV-infected and Uninfected Individuals (R21 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to support innovative studies to identify and understand the immunological responses that mediate protection from Mycobacterium tuberculosis (Mtb) infection or following vaccination with Bacillus Calmette-Gurin (BCG) or investigational vaccines. Studies may focus on any stage of mycobacterial infection and may include HIV-infected or uninfected individuals. Development of novel functional assays to assess host response and inclusion of immune profiling and systems biology approaches are encouraged.

Combination Prevention Solutions to Reach Epidemic Control among High Risk, Priority Populations in High Burden Areas in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)

HIV/AIDS remains the most pressing health problem and leading cause of death in South Africa. Despite high coverage levels for HIV/AIDS services, South Africa has not achieved epidemic control. Adolescent Girls and Young Women (AGYW) aged 15-19 have an HIV prevalence rate eight times higher than boys of the same age. Prevalence rises dramatically as young women get older, from 5.6% among 15 to 19 year olds to 17.4% among 20-24 year olds.

HIV Prevention, Care, and Treatment Support for Church-related Hospitals and Clinics in the Republic of Zimbabwe under the President's Emergency Plan for AIDS Relief (PEPFAR)

Zimbabwe has a generalized HIV epidemic with an estimated 1.4 million people living with HIV (PLHIV). Adult prevalence aged 15-49 is 14.0%, down from 18.1% in 2015. Incidence among adults is 0.47%, and the 18-month mother to child transmission (MTCT) rate is 6.74%. However, testing, treatment, and viral suppression coverage all lag behind the 95-95-95 targets. Zimbabwe’s Ministry of Health and Child Care (MOHCC) has highlighted human resource challenges across the continuum of service delivery.

Modeling HIV Neuropathology Using Microglia from Human iPSC and Cerebral Organoids (R01 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) invites research grant applications to study the cellular and molecular mechanisms delineating the neuropathophysiology of HIV-associated neurological disorders (HAND) in the setting of long-term combination antiretroviral therapy (cART) conditions using induced microglia and cerebral organoids generated from patient derived induced pluripotent stem cell (iPSC) lines.

Strengthening Combination Prevention and Testing Services among Inmates to Reduce HIV Infections and to Reduce Morbidity and Mortality in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)

This award will focus on strengthening HIV combination prevention within all correctional facilities in South Africa. Innovative combination prevention interventions will address HIV risk and increase protective behaviors among inmates, accompanied by voluntary medical male circumcision, and HIV Testing Services (HTS). The target populations include inmates, released individuals, and Department of Correctional Services (DCS) staff.

Optimizing Performance by Improving Quality (OPIQ) in HIV and HIV/TB Programs in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)

The goal of this NOFO is to improve performance of HIV and TB key indicators and programmatic areas by providing technical assistance (TA) using Quality Improvement (QI) methodologies to PEPFAR South Africa’s implementing partners (IPs) and the South African Government’s (SAG) National, Provincial, and District Departments of Health (DOH).

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