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Approaches to Eliminate HIV and Opportunistic Pathogens from Oral Reservoirs (R01)

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Grant Amount: NIDCR intends to commit $3.5 million in FY2015, including $1.5 million in HIV/AIDS-related research and $2 million in non-HIV/AIDS-related research, to fund a total of 6-10 new awards. In spite of significant therapeutic accomplishments after 30 years of research on HIV and the global AIDS epidemic, abolishing HIV and its oral infectious comorbidities has yet to be achieved. For this reason, the goal of this FOA is to support novel basic and translational research projects that focus on the biology of residual oral reservoirs for HIV and opportunistic oral pathogens.

Role of the Microbiome in HIV-1 Vaccine Responses (R21)

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Grant Amount: Unspecified. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research focused on elucidating the role of the microbiome in shaping the host immune responses to HIV-1 transmission and vaccination in the gastrointestinal and genital mucosa.

Role of the Microbiome in HIV-1 Vaccine Responses (R01)

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Grant Amount: Unspecified. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research focused on elucidating the role of the microbiome in shaping the host immune responses to HIV-1 transmission and vaccination in the gastrointestinal and genital mucosa.

Mucosal Environment and HIV Prevention (MEHP II) (R01)

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Grant Amount: The NIAID intends to commit $1,200,000 in FY 2015 to fund 1-2 awards. The purpose of this FOA is to stimulate research to better understand and optimize the interaction of genital (female and male) and gastrointestinal (GI) tract mucosa with non-vaccine biomedical prevention (nBP) candidates and strategies with the long-term goal of enhancing the safety and efficacy of HIV prevention interventions.

Extracellular Vesicles in HIV/AIDS and Substance Abuse (R21)

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Grant Amount: The combined budget for direct costs for the two year project period may not exceed $275,000. No more than $200,000 may be requested in any single year. The purpose of this FOA is to encourage research projects that investigate extracellular vesicles in HIV infection/progression or as potential HIV/AIDS biomarkers or therapeutics. Proposed projects must also explore the potential impact of exposure to substances of abuse.

Extracellular Vesicles in HIV/AIDS and Substance Abuse (R01)

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Grant Amount: NIDA intends to commit $2 million in FY2015 to fund a combined total of 6-9 R21 and R01 awards. The purpose of this FOA is to encourage research projects that investigate extracellular vesicles in HIV infection/progression or as potential HIV/AIDS biomarkers or therapeutics. Proposed projects must also explore the potential impact of exposure to substances of abuse.

Innovative Assays to Quantify the Latent HIV Reservoir (R01)

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Grant Amount: NIAID intends to commit $1.3 million in FY 2015 to fund 2-4 awards. The goal of this FOA is to support research on the development of innovative high-throughput approaches for quantifying the very low levels of latently infected cells that persist in HIV-positive individuals on HAART. Ideally, a new assay is needed that specifically quantifies resting CD4 memory T cells that contain integrated, replication-competent provirus.

Multidisciplinary Studies of HIV and Viral Hepatitis Co-Infection (R01)

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Grant Amount: Unspecified. The purpose of this Funding Opportunity Announcement (FOA) is to fill gaps in our understanding of (a) the pathogenic interactions between HIV and hepatitis viruses, (b) co-morbidities associated with HIV/hepatitis virus co-infection, and c) the effectiveness of interferon-free direct-acting antiviral drug regimens to treat HIV/HCV co-infection.

Multidisciplinary Studies of HIV and Viral Hepatitis Co-Infection (R21)

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Grant Amount: Unspecified. The purpose of this Funding Opportunity Announcement (FOA) is to fill gaps in our understanding of (a) the pathogenic interactions between HIV and hepatitis viruses, (b) co-morbidities associated with HIV/hepatitis virus co-infection, and c) the effectiveness of interferon-free direct-acting antiviral drug regimens to treat HIV/HCV co-infection.

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